Breast cancer scrna
WebSep 6, 2024 · Cancer is a complex and heterogeneous disease with hundreds of types and subtypes spanning across different organs and tissues, originating in various cell types [1,2].For example, breast cancer is highly heterogeneous with different subtypes that lead to varying clinical outcomes, including prognosis, treatment response, and changes in … WebApr 12, 2024 · Using single-cell DNA (scDNA-seq) or RNA (scRNA-seq) sequencing data with other computational tools has helped drive a new generation of information that can paint a clearer picture of cancer development. ... Yun Yan, Ph.D., and colleagues identified cell types that are reprogrammed in malignant triple-negative breast cancer, providing …
Breast cancer scrna
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WebApr 12, 2024 · Using single-cell DNA (scDNA-seq) or RNA (scRNA-seq) sequencing data with other computational tools has helped drive a new generation of information that can … WebFeb 25, 2024 · Perspectives of Single-Cell Technologies in Breast Cancer Research. Although the heterogeneous cell populations in the TME stand out as the key barrier to delineate the tumor ecosystems, the advances in single-cell technologies, in particular scRNA-seq and mass cytometry, has revolutionized breast cancer research.
WebFeb 9, 2024 · Here, we employed scRNA-seq to dissect the heterogeneity between primary tumor and metastatic lymph node and associated critical factors in regulating the lymph node metastasis of breast cancer. The transcriptomic profiles of a total of 30 213 cells from primary tumors, negative and positive lymph nodes (PLs) were acquired. WebSingle-cell RNA sequencing in breast cancer: Understanding tumor heterogeneity and paving roads to individualized therapy 1 BACKGROUND. Traditional RNA sequencing (RNA-seq) is performed using bulk RNA …
WebSingle-cell RNA sequencing (scRNA-seq) is a novel technology that allows transcriptomic analyses of individual cells. During the past decade, scRNA-seq … WebNational Center for Biotechnology Information
WebMar 31, 2024 · For instance, research that focuses on triple-negative breast cancer (TNBC, the most vicious subtype of breast cancer usually with bad prognosis) has harnessed scRNA-seq for investigation of the altered transcriptome of drug-resistant cells with chemotherapy, thus discovering that, despite drug-resistant clones existing at the …
WebJun 9, 2024 · Compared to traditional bulk RNA sequencing, which reflects the average profiles of gene mutation and expression, scRNA-seq examines the multiomics features of individual cells, thus mapping the TME among various tumors, such as breast cancer . These scRNA-seq data provide supporting evidence for accurate molecular subtyping … ticking tessWebBreast cancer screening is the medical screening of asymptomatic, apparently healthy women for breast cancer in an attempt to achieve an earlier diagnosis. The assumption … the longkeeper pukekoheWebJan 19, 2024 · Triple-negative breast cancer (TNBC) is a highly heterogeneous disease with different molecular subtypes. Although progress has been made, the identification of TNBC subtype-associated biomarkers is still hindered by traditional RNA-seq or array technologies, since bulk data detected by them usually have some non-disease tissue … ticking texts 2WebJul 20, 2024 · Title. Divergent resistance mechanisms to HER2-targeted therapies in breast cancer. Organisms. Homo sapiens Mus musculus. Experiment type. Expression profiling by high throughput sequencing. Genome variation profiling by high throughput sequencing. Summary. This SuperSeries is composed of the SubSeries listed below. the long kiss goodbye 2006WebApr 6, 2024 · Triple-negative breast cancer (TNBC) is an aggressive subtype of mammary carcinoma characterized by low expression levels of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). ... and cell-cell communication analysis on the scRNA-seq data retrieved from Gene Expression … the long kiss goodbye castWebMay 12, 2024 · Integrative analyses of scRNA-seq and scATAC-seq revealed CXCL14 as a key regulator of lymph node metastasis in breast cancer. Lawson et al. [ 128 ] analyzed the gene expression of metastatic breast cancer at different stages by SCS and found that gene expression levels of metastatic tumor cells in early lesions were significantly … the long kiss goodbye imdbWebNov 9, 2024 · To better understand the transcriptional heterogeneity in breast cancer, we recently performed single-cell RNA sequencing (scRNA-seq) in primary patient samples and developed a novel computational method that can predict immature cell populations in silico . Using our scRNA-seq data, bulk tumor expression deconvolution, lineage tracing, and ... the long kiss goodbye movie cast