Novel inhat repressor
WebSep 26, 2024 · Orthologous to human NOC2L (NOC2 like nucleolar associated transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2024] Other designations. nucleolar complex protein 2 homolog, NOC2-like protein, novel INHAT repressor, nucleolar complex associated 2 homolog, protein NOC2 homolog. GeneRIFs: … WebShideng Bao's 115 research works with 17,964 citations and 14,742 reads, including: Novel INHAT repressor drives glioblastoma growth by promoting ribosomal DNA transcription in glioma stem cells
Novel inhat repressor
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WebSep 8, 2014 · Novel INHAT repressor (NIR; also called NOC2L) is a transcriptional corepressor with INHAT activity ( 10 ). Conventional inhibitors of histone deacetylases (HDACs) do not suppress NIR activity, suggesting that NIR does not function by attracting HDACs to its target promoters ( 10 ). WebIn this work we characterize the novel corepressor NIR (Novel INHAT Repressor). NIR binds to nucleosomes and histones and blocks their acetylation by histone acetyltransferases, thus acting as a bona fide INHAT. We identify the tumor suppressor p53 as a NIR-interacting partner and demonstrate that, upon recruitment, NIR inhibits p53-activated ...
WebNovel inhibitor of histone acetyltransferase repressor (NIR) is a transcriptional corepressor that can bind to p53 at promoters and suppress p53-transcriptional activity by inhibiting … WebBut Booth explains that for a narrator to be unreliable, they must either misreport, misinterpret, misevaluate, underreport, under-interpret, or under-evaluate. This can be on …
WebDec 1, 2005 · NIR (Novel INHAT Repressor) is ubiquitously expressed throughout embryonic development and adulthood. NIR is a potent transcriptional corepressor that is not … WebDec 13, 2011 · Author intrusion can come into a story with word choices. Some writers like to pretty up their prose, add a dash of the poetic or use fancy words in place of cheap, …
WebNIR (Novel INHAT Repressor) is ubiquitously expressed throughout embryonic development and adulthood. NIR is a potent transcriptional corepressor that is not blocked by histone deacetylase inhibitors and is capable of silencing both …
WebJan 1, 2024 · NIR, a novel INHAT, negatively regulates the transcription activity of tumor repressor p53. However, if NIR functions in the tumorigenesis dependent on the regulation of p53 remains unknown. ... NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Genes Dev., 19 (2005), pp. 2912-2924. CrossRef View … tsh-ifccとはWebSep 10, 2011 · Negative regulation of p53 activity by NIR (novel INHAT repressor) has been suggested as a regulatory mechanism of p53 activity . In this study, we expanded the role of INHAT regulator SET/TAF-Iβ to the important non-histone protein p53. We showed that INHAT subunit SET/TAF-Iβ plays a novel repressive role in p53 activity due to the ... philosopher\u0027s index onlineWebProduct name Anti-NOC2L antibody Description Rabbit polyclonal to NOC2L Host species Rabbit Tested applications Suitable for: IHC-P, WB more details Species reactivity Reacts with: Human Immunogen Recombinant fragment (GST-tag) corresponding to Human NOC2L (internal sequence). Database link: Q9Y3T9 Positive control philosopher\u0027s index怎么搜索WebJan 1, 2024 · OncoTargets and therapy Background Novel inhibitor of histone acetyltransferase repressor (NIR), a corepressor with a novel inhibitor of histone acetyltransferase (INHAT) activity, has been reported to be a negative modulator of p53 and a regulator of the cell cycle in cancer cells. philosopher\\u0027s indexWebNIR (Novel INHAT Repressor) is ubiquitously expressed throughout embryonic development and adulthood. NIR is a potent transcriptional corepressor that is not blocked by histone deacetylase inhibitors and is capable of silencing both … philosopher\\u0027s index databaseWebJan 17, 2024 · NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). NOC2L is found to have two INHAT function domains and regulates histone acetylation in a histone … tsh ifcc 基準値WebSep 8, 2014 · (PDF) Novel INHAT Repressor (NIR) is required for early lymphocyte development Novel INHAT Repressor (NIR) is required for early lymphocyte development … philosopher\u0027s index database